Browsing by Author "Ozdemir, Semra"
Now showing items 1-12 of 12
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Alterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas
Kilinc, Devran; Ozdemir, Oztuerk; Ozdemir, Semra; Korgali, Esat; Koksal, Binnur; Uslu, Atilla; Gultekin, Yener E. (MARY ANN LIEBERT INC, 2012)Hypermethylated genomic DNA is a common feature in tumoral tissues, although the prevalence of this modification remains poorly understood. We aimed to determine the frequency of five tumor suppressor (TS) genes in prostate ... -
Association between ABCB1 (MDR1) Gene 3435 C > T Polymorphism and Colchicine Unresponsiveness of FMF Patients
Ozen, Filiz; Silan, Coskun; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma; Ozdemir, Semra; Atik, Sinem; Ozdemir, Ozturk (TAYLOR & FRANCIS LTD, 2011)The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and ... -
Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus
Timucin, Meryem; Alagozlu, Hakan; Ozdemir, Semra; Ozdemir, Ozturk (KOWSAR PUBL, 2013)Background: To treat viral infection of chronic hepatitis C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in ... -
Increased T-Allele Frequency of 677 C > T Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Differentiated Thyroid Carcinoma
Ozdemir, Semra; Silan, Fatma; Hasbek, Zekiye; Uludag, Ahmet; Atik, Sinem; Erselcan, Taner; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2012)Background: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic ... -
Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C > T Gene Polymorphism in Differentiated Thyroid Cancers
Ozdemir, Semra; Uludag, Ahmet; Silan, Fatma; Atik, Sinem Yalcintepe; Turgut, Bulent; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine ... -
Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: Relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume
Turgut, Bulent; Elagoz, Sahande; Erselcan, Taner; Koyuncu, Ayhan; Dokmetas, H. Sebila; Hasbek, Zekiye; Ozdemir, Semra; Aydin, Cengiz (MARY ANN LIEBERT INC, 2006)In addition to tumor size, it has been suggested that P-glycoprotein (P-gp) expression and/or oxyphilic cell content in parathyroid adenomas has an important influence on the results of technetium 99m methoxyisobutylisonitrile ... -
The prevalence of VKORC1 1639 G > A and CYP2C9*2*3 genotypes in patients that requiring anticoagulant therapy in Turkish population
Silan, Coskun; Dogan, Omer Tamer; Silan, Fatma; Kukulguven, Fatma Mutlu; Asgun, Halil Fatih; Ozdemir, Semra; Uludag, Ahmet; Atik, Sinem; Gungor, Buket; Akdur, Secil; Aksulu, Hakki Engin; Ozdemir, Ozturk (SPRINGER, 2012)The aim was to investigate the prevalence of VKORC1 and CYP2C9 genotypes in patients requiring anticoagulant therapy in two different region's populations of Turkey. The recent cohort included 292 patients that needed ... -
The Proto-Oncogene KRAS and BRAF Profiles and Some Clinical Characteristics in Colorectal Cancer in the Turkish Population
Ozen, Filiz; Ozdemir, Semra; Zemheri, Ebru; Hacimuto, Gizem; Silan, Fatma; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2013)Objectives: The aim of the current study was to investigate the prevalence and predictive significance of the KRAS and BRAF mutations in Turkish patients with colorectal cancer (CRC). Methods: Totally, 53 fresh tumoral ... -
Tissue specific epigenetic silencing of the distinct tumor suppressor genes in lung cancer
Arslan, Sulhattin; Karadayi, Sule; Ozdemir, Ozturk; Sahin, Ekber; Ozdemir, Semra; Akkurt, Ibrahim (ACADEMIC JOURNALS, 2010)The role of aberrant methylation of the cytosine-guanine dinucleotide islands in the promoter region of tumor suppressor genes in lung cancer development is increasingly recognized. DNAs extracted from cancer tissue biopsies ...